jneuroJournal of Neurology and NeuropsychiatrycoVolume 1 Issue 2 (July-Dec)MultidisciplinaryEnglish6 Months NNY2025094NeuroscienceSubsequent Effects of Glyphosate and the Neuropeptide PACAP on Neurobehavioral Functions in Mice.EnglishY1718Benmansour Emna1EnglishN2EnglishY3EnglishYEl Hafedh ElMouhab2EnglishYAmine Cherif10.8333px;">2EnglishYMaha MezghaniKhemakhem¹EnglishYGlyphosate (GLY), the most widely used herbicide worldwide, has been linked to neurological dysfunctions, while Pituitary adenylate cyclase-activating polypeptide (PACAP) exhibits neuroprotective properties. This short report investigates the effects of GLY exposure and PACAP treatment on neurobehavioral functions in Swiss albino mice. Behavioral assessments including Tail Suspension Test, Dark/Light Box, Elevated-Plus-Maze, and Open Field Test revealed that repeated GLY exposure induces anxiety- and depression-like behaviors, whereas co-treatment with PACAP alleviates these effects. Our findings highlight PACAP as a potential therapeutic candidate against glyphosate-induced neurobehavioral impairments.EnglishGlyphosate, Neurobehavioral functions, Anxiety and depression, Mice modelhttps://jneuro.clsconf.com/admin/abstract?id=25References1619References:Duke SO, Powles SB. Glyphosate: a once?in?a?century herbicide. Pest Management Science. 2008;64(4):319-325. Doi: https://doi.org/10.1002/ps.1518Kamel F, Hoppin JA. Association of pesticide exposure with neurologic dysfunction and disease. Environmental Health Perspectives. 2004;112(9):950-958. Doi: https://doi.org/10.1289/ehp.7135Miyata A, Arimura A, Dahl RR, Minamino N, Uehara A, Jiang L, Culler MD, Coy DH. Isolation of a novel 38 residue hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochemical and Biophysical Research Communications. 1989;164(1):567-574. Doi: https://doi.org/10.1016/0006-291X(89)91757-9Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H. Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacological Reviews. 2000;52(2):269-324. Doi: PMID:10835102Worek F, Wille T, Koller M, Thiermann H. Toxicology of organophosphorus compounds in view of an increasing terrorist threat. Archives of Toxicology. 2016;90(9):2131-2145. Doi: https://doi.org/10.1007/s00204-016-1724-6